Today whether you are haunted by the rheumatoid arthritis or the psoriasis,the drug I will mention below may be a fillip to you.So,Koffee Pharm Co.,Ltd show to you.
Tofacitinib (INN) is a drug of the janus kinase (JAK) inhibitor class, discovered and developed by the National Institutes of Health and Pfizer. Tofacitinib is marketed as Xeljanz and Jakvinus.
It is currently approved for the treatment of rheumatoid arthritis (RA) in the United States and other countries.It has demonstrated effectiveness in the treatment of psoriasis in Phase 3 studies. It is being studied for treatment of inflammatory bowel disease, and other immunological diseases, as well as for the prevention of organ transplant rejection.
In November 2012, the U.S. FDA approved tofacitinib "to treat adults with moderately to severely active rheumatoid arthritis who have had an inadequate response to, or who are intolerant of, methotrexate." It was later approved in Japan, Switzerland and others (but not the EU). It is marketed as Xeljanz in all regions except for Russia where it will be marketed as Jakvinus or Jaquinus.
It is an inhibitor of the enzyme janus kinase 1 (JAK1) and janus kinase 3 (JAK 3) , which means that it interferes with the JAK-STAT signaling pathway, which transmits extracellular information into the cell nucleus, influencing DNA transcription.
In a mouse model of established arthritis, tofacitinib rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue. This efficacy in this disease model correlated with the inhibition of both JAK1 and 3 signaling pathways, suggesting that tofacitinib may exert therapeutic benefit via pathways that are not exclusive to inhibition of JAK3.
What`s more,expert Kevin from Koffee Pharm Co.,Ltd suggested that you shall check with your doctor immediately if any of the following side effects occur while taking tofacitinib:bladder pain,bloody or cloudy urine,blurred vision,body aches or pain,chills,cough,difficulty breathing,dizziness,ear congestion,fever,frequent urge to urinate,headache,loss of voice etc.
If you want to know more information, please contact sophia@koffeepharm.com
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