Pterostilbene

Information of Pterostilbene

Pterostilbene is a natural supplement that is said to improve brainpower and memory, protect against aging, reduce signs of inflammation and improve energy metabolism and hormone balance. Very similar to Resveratrol, Pterostilbene is a plant-derived chemical which fights major causes of age-related cognitive decline, including free radical damage. It also contributes to healthy mental function by improving vascular health and regulating the loss of dopamine.

Effect

Pterostilbene appears to reduce blood pressure in hypercholesterolemic adults, and the addition of grape seed extract (which mitigates adverse cholesterol effects) adds
to the benefits to blood pressure.In hypercholesterolemic adults not on cholesterol lowering medication, pterostilbene appears to reduce HDL mildly.
An increase in LDL cholesterol has been noted with oral ingestion of pterostilbene in hypercholesterolemic adults, mitigated by grape seed extract
An increase in total cholesterol, attributable to LDL, has been seen in hypercholesterolemic adults given pterostilbene.
A slight decrease in weight has been seen in adults given pterostilbene supplementation alongside an increase in cholesterol; the two appear linked, as the addition of

grape seed extract appeared to mitigate both.

Supplementation of pterostilbene in hypercholesterolemic adults does not appear to influence blood glucose relative to control.
Supplementation of pterostilbene in hypercholesterolemic adults does not appear to influence blood glucose relative to control.
Supplementation of pterostilbene in hypercholesterolemic adults does not appear to influence liver enzymes (ALP, AST) relative to control.
There do not appear to be any interactions on triglycerides in adults with normal triglyceride levels given pterostilbene supplementation.
The multiple benefits of pterostilbene in the treatment and prevention of human disease have been attributed to its antioxidant, anti-inflammatory, and anticarcinogenic properties leading to improved function of normal cells and inhibition of malignant cells. Treatments with blueberry extract and PM in similar disease models have yielded paralleled results possibly due to the antioxidant activity and underlying mechanisms of pterostilbene. The evidence presented in this review shows that pterostilbene reduces oxidative stress (OS) and production of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2) and superoxide anion (O2?), which are implicated in the initiation and pathogenesis of several disease processes. In addition, various cell lines treated with pterostilbene have shown increased expression of the antioxidants catalase, total glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), and superoxide dismutase (SOD).
“What can foreknow is,Pterostilbene will play a more and more important role on reducing carcinogenic incidence in the future.”expert Sophia from Koffee Pharm Co.,Ltd said.

How to Take

Supplementation of pterostilbene for the purpose of aiding glucose and lipid metabolism tends to be around 20- 40mg/kg oral ingestion in rats, which is an estimated human dosage range of:

215-430mg for a 150lb person
290-580mg for a 200lb person
365-730mg for a 250lb person

Possible anxiolytic properties of pterostilbene are seen at 1-2mg/kg in mice, which is an estimated human dose of:

5-11mg for a 150lb person
3-14.5mg for a 200lb person
9-18mg for a 250lb person

Which is notable as 5-10mg/kg in these mice (slightly over double the dose) has failed to have the same anxiolytic effects, suggesting a bell-curve that may favor lower dosages such as is found in food consumption rather than higher dosages from supplementation.

Avoid Pterostilbene Side Effects

With no major side effects reported, there are few warnings about Pterostilbene dosages. The general consensus is that Pterostilbene is most effective at 300 mg per day. However, it is known to have a fairly short half life of about 100 minutes or less. For that reason, many users try to split their daily dosage into 2 parts, taking one in morning and one later in the day. Pterostilbene can be found as an ingredient in the Alpha Brain nootropic stack by Onnit Labs. This popular brain supplement combines this compound with other natural cognitive enhancers such as L-Theanine, Bacopa Monnieri, Vinpocetine and Huperzine A which can also protect the brain and improve mental function.