Cordycepin

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Cordycepin is also known as 3’-deoxyadenosine, a nucleoside analog and a transcription chain terminator. When Cordycepin is introduced to cells undergoing DNA replication, it produces a defective DNA that triggers cells to undergo apoptosis (programmed cell death).
Currently, the National Cancer Institute in collaboration with a pharmaceutical company has initiated a Phase I clinical study of Cordycepin as a potential treatment agent.
However, we believe that the whole Cordyceps mushroom would be more potent than a single extract such as Cordycepin alone. We believe that the synergistic effects of Cordyceps polysaccharides, adenosine, cordycepic acid, and cordycepin would be much greater than those achieved by the use of Cordycepin alone.
Following are results of anti-aging studies of Cordyceps on various body systems.
Cellular ATP: Cordyceps improves sexual function (17) and is traditionally used for fatigue (18).
Hepatic system (the liver): Cordyceps activates Kupffer cell function, increases SOD and glutathione peroxidase in the liver, raises plasma albumin, and inhibits inflammation and liver fibrosis (1-3).
Cardiovascular system: Cordyceps inhibits thrombus formation, hypotensive, mildly inhibits platelet aggregation, vasodilation, reduces heart rate, reduces arrhythmia induced by aconitine, and is hypolipidemic (13-16).
Immune system: Cordyceps modulates cellular immune function, inhibits humoral immune hyperfunction, prevent inhibition of NK cells by cyclophosphamide, protects T helper cells from immunosuppression effects of prednisolone acetate and cyclophosphamide, prolongs allograft survival time, and increases spleen weight (4-6).
Endocrine system: Cordyceps increases corticosteroid production (differently than ACTH) and stimulates bone marrow hematogenesis function (7-8).
Malignant cells: Cordyceps inhibits Ehrlich ascites carcinoma, Meth A fibrosarcoma, K562, Jurkat, WM-1342, HL-60, and RPMI-8226 cell lines, and promotes differentiation (9-12).
Moreover，based on the advice of expert Kevin(Koffee Pharm Co.,Ltd),one shall take Cordycepin:1 to 3 grams per day for maintenance; 3 to 6 grams per day for optimal effects.