PRL-8-53

PRL-8-53 is a nootropic research compound first synthesized in the 1970’s by Dr Nikolaus Hansl while working at Creighton University. The compound takes its name from creator’s company Pacific Research Labs who were also the (now expired) patent holders. Very little research on this compound is available online. What is available appears to have been conducted by the old patent holder.

The single study involving humans showed PRL-8-53 improved word recollection scores both 24 and 96 hours after initial memorization. Given the low amount of evidence available for this nootropic, we thought it relevant to reference a journal article in which the creator discusses the compound and numerous other human trials it was used in.

Anecdotal reports for this seem favorable, though in the absence of reliable published research and data for prolonged use in humans, it’s not something we can recommend.

The limited research for this nootropic suggests that it’s memory enhancing. The compound creator also discusses other benefits, which we cover below. Given the low amount of research on this compound and an unknown mechanism of action, we can’t advise on what to stack this with. If you do decide to experiment with it, consider taking PRL-8-53 without other nootropics to reduce possible interactions.

The single published human study used 5mg of PRL-8-53 and found it enhanced recall on a word-remembering test.  The patent for the compound mentions an oral dose of 0.01mg/kg per dose, taken 3 times per day.