The benefit of Sunifiram

Sunifiram, also known as 1-benzoyl-4-propanoylpiperazine is a nootropic that was only first researched in the year 2000. It has a similar chemical structure to Piracetam but initial studies show that it is significantly more potent than this widely used racetam. Sunifiram so far shows very positive results as memory enhancer and it is currently being investigated for potential treatment of Alzheimer’s and other diseases related to cognitive decline.

Sunifiram works very similarly to other racetams by stimulating many of the same receptors just in different ways. The primary effect of taking Sunifiram is stimulation of AMPA receptors (hence which this drug is considered an AMPAkine). In clinical trials, patients given the AMPA antagonist NBQX and then given Sunifiram saw increased AMPA receptor activity. AMPA receptors are responsible for how much glutamate is produced in the brain.

Glutamate is perhaps the most important neurotransmitter in the brain, responsible for communicating excitatory transmissions, forming connections between synapses, and for regulating brain cell survival. Glutamate is highly involved in brain metabolism as well as synaptic plasticity. Too little glutamate and your cognitive abilities will be greatly impaired, resulting in less attention span, poor ability to learn information and difficulty remembering. Sunifiram can help reverse this by raising levels of glutamate so your brain performance is increased. Especially when engaging in long periods of mental exertion, you will find that Sunifiram makes it easier to remember information and learn new concepts.

Sunifiram also effects levels of acetylcholine in the brain just like Piracetam, Pramiracetam, Aniracetam, Oxiracetam and other racetam nootropics. Studies have established that taking Sunifiram is Cholinergic meaning that it causes more of this neurotransmitter to be released. Increased presence of Acetylcholine in the cerebral cortex leads to improved thinking, perception, alertness, learning, memory and focus. Acetycholine makes it easier for your left and right brain hemispheres to communicate as well which can cause you to recognize patterns and connections more effectively as well as improve basic social skills like talking in group settings.

Sunifiram is incredibly concentrated compared even to the strongest racetams like Pramiracetam. You will see positive effects from a dosage as small as 4 mg though many people typically take between 5-8 mg at a time. A Sunifiram dose of 10 mg is more likely to cause a stimulant effect similar to Adderall. Taking a 10 mg Sunifiram dosing is not toxic and not likely to cause serious negative side effects, however you may experience increased body temperature and perspiration. You should start with a half dose of 3 mg for your first week or so of taking this ampakine nootropic and then only increase the dosage if you feel comfortable.