Tianeptine Sodium
$49.90 – $465.00
The tianeptine sodium salt is a tricyclic antidepressant. Its antidepressant mechanism is different from traditional tricyclic antidepressants. It can increase the reuptake of 5-HT in the synaptic space and may increase 5-HT nerves.
Description
Product Information:
Name: Tianeptine sodium
CAS No.: 30123-17-2
Molecular Formula: C21H24ClN2NaO4S
Molecular Weight: 458.93
Appearance:White to yllwishs powder,very hygroscopic.
What is Tianeptine sodium?
The tianeptine sodium salt is a tricyclic antidepressant. Its antidepressant mechanism is different from traditional tricyclic antidepressants. It can increase the reuptake of 5-HT in the synaptic space and may increase 5-HT nerves. The effect of meta conduction. No affinity for choline or adrenaline receptors. The antidepressant effect is similar to tricyclics, but the tolerability is better than tricyclics. In animal experiments, it can increase the spontaneous activity of pyramidal cells in the hippocampus and accelerate the recovery of their function after inhibition; Chemicalbook can increase the reabsorption of serotonin by neurons in the cerebral cortex and hippocampus. Tianeptine sodium is absorbed quickly and completely in the digestive tract. The distribution is rapid, and the PPB is as high as 94%. It is completely metabolized in the liver through β-oxidation and N-demethylation, and the final clearance T1/2 is short, which is 2.5 hours. A very small amount of the original drug (8%) is excreted from the kidneys, mainly due to the excretion of its metabolites in the urine. . In patients with renal insufficiency, the clearance of T1/2 was extended by 1 hour.
Side effects
Common symptoms include dry mouth, nausea, drowsiness, dizziness, headache, insomnia, nightmares, weight gain, and constipation. Uncommon myalgia, back pain, ventricular arrhythmia, orthostatic hypotension, Chemicalbook palpitations, slow heart rate, tremor, anxiety, irritability, hot flashes, flushing, mouth pain, flatulence, abdominal pain, serum C Elevated aminotransferase, skin rash, etc.
Matters needing attention
1. Use caution in patients with cardiovascular disease, gastrointestinal disease, and severe renal insufficiency.
2. Depressed patients with inherited suicidal tendencies must be closely monitored when taking this drug, especially at the beginning of treatment.
3. If general anesthesia is required, the anesthesiologist should be informed that the patient is taking this medicine, and the medicine should be stopped 24 or 48 hours before the operation. When emergency surgery is required, there is no need to have a drug withdrawal period, but preoperative monitoring should be carried out.
4. As with all drugs for the treatment of mental illness, if the treatment is interrupted, the dose should be gradually reduced for more than 7 to 14 days.
5. Some patients will experience decreased alertness. Drivers or operators of Chemicalbook machines should be aware of the danger of drowsiness when taking this medicine.
6. Before starting treatment with this product, monoamine oxidase inhibitor drugs must be stopped for 2 weeks. However, patients who originally took this product to be treated with monoamine oxidase inhibitor drugs only need to stop taking this product for 24 hours.
7. Animal experiments show that the drug has no adverse effects on reproductive function. Only a few drugs pass through the placenta, and no accumulation in the fetus is seen. However, there is no relevant clinical research data in humans. Avoid taking this medicine during pregnancy.
8. Tricyclic antidepressants can be secreted into breast milk. It is recommended not to breastfeed during the medication.
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