Oleoylethanolamide (OEA)
$49.90 – $479.00
Oleoylethanolamide is a type of N-(long-chain acyl)ethanolamine, which is the ethanolamide of oleic acid. Monounsaturated analog of the endocannabinoid anandamide It has the effect of PPARalpha agonist and EC 3.5.1.23 (ceramidase) inhibitor. It is an N-(long-chain acyl)ethanolamine, an endocannabinoid, and an N-acylethanolamine 18:1. It is derived from oleic acid.
Description
Product Information:
Name: Oleoylethanolamide (OEA)
CAS No.: 111-58-0
Molecular Formula: C20H39NO2
Molecular Weight: 325.53
Appearance:Fine white crystal powder
What is oleoylethanolamide (OEA)?
Oleoylethanolamide is a type of N-(long-chain acyl)ethanolamine, which is the ethanolamide of oleic acid. Monounsaturated analog of the endocannabinoid anandamide It has the effect of PPARalpha agonist and EC 3.5.1.23 (ceramidase) inhibitor. It is an N-(long-chain acyl)ethanolamine, an endocannabinoid, and an N-acylethanolamine 18:1. It is derived from oleic acid.
Side effects
Weight gain
Edema
Anemia
Description
oleoyl ethanolamide (OEA) is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-α) agonist. It is a naturally occurring glycol amide lipid that can regulate the food intake and body weight of vertebrates ranging from mice to pythons.
OEA is a shorter, monounsaturated analog of the endocannabinoid anandamide, but unlike anandamide, it acts independently of the cannabinoid pathway and regulates PPAR-α activity to stimulate lipolysis.
OEA is produced by the small intestine after eating in two steps. First, N-acyltransferase (NAT) activity connects the free amino terminus of phosphatidylethanolamine (PE) to the oleoyl group (an acyl group) derived from sn-1-oleoyl-phosphatidylcholine, where Contains the sn-1 position of fatty acid oleic acid. This produces N-acylphosphatidylethanolamine, which is then decomposed (hydrolyzed) into phosphatidic acid and OEA by N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD). The biosynthesis of OEA and other biologically active fatty amides is regulated by bile acids.
OEA has been shown to bind to the new cannabinoid receptor GPR119. OEA is considered to be the endogenous ligand of the receptor.
According to reports, OEA can extend the lifespan of the nematode Caenorhabditis elegans by interacting with lysosomal molecules.
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